Proteins are major building blocks of life. The protein content of a cell and an organism
provides key information for the understanding of biological processes and disease. Despite …

Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

Despite tremendous gains over the past decade, methods for characterizing proteins have
generally lagged behind those for nucleic acids, which are characterized by extremely high …

Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput |
Nature Methods Skip to main content Thank you for visiting nature.com. You are using a browser …

Proteins perform a huge number of central functions in living organisms, thus all the new
techniques allowing their precise, fast and accurate characterization at single-molecule level …

This study describes a novel Dean flow assisted cell ordering system which is connected to
an electrospray ionization-mass spectrometer for the detection of lipids in a single-cell. This …

DNA sequencing using nanopores, so-named nanopore sequencing, is one of the most
promising and revolutionary DNA sequencing technologies to provide the order and the type …

Electrospray ionization is widely used to generate vapor phase ions for analysis by mass
spectrometry in proteomics research. However, only a small fraction of the analyte enters the …

Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence
is often used as a surrogate for mutation and increased cancer risk. Interest in DNA adducts …