[HTML][HTML] CIB1: a small protein with big ambitions

TM Leisner, TC Freeman, JL Black… - The FASEB Journal, 2016 - ncbi.nlm.nih.gov
Calcium-and integrin-binding protein 1 (CIB1) is a small, ubiquitously expressed protein that
was first identified as an intracellular binding partner of a platelet-specific α-integrin …

Targeted delivery of siRNA lipoplexes to cancer cells using macrophage transient horizontal gene transfer

EC Wayne, C Long, MJ Haney, EV Batrakova… - Advanced …, 2019 - Wiley Online Library
Delivery of nucleic acids into solid tumor environments remains a pressing challenge. This
study examines the ability of macrophages to horizontally transfer small interfering RNA …

The emerging roles of CIB1 in cancer

X Wang, X Peng, X Zhang, H Xu, C Lu, L Liu… - Cellular Physiology and …, 2017 - karger.com
Calcium and integrin-binding protein 1 (CIB1) is an EF-hand calcium binding protein, which
is involved in many cellular processes, including calcium signaling, cell survival and …

CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival

V Michel, KT Booth, P Patni, M Cortese… - EMBO Molecular …, 2017 - embopress.org
Defects of CIB 2, calcium‐and integrin‐binding protein 2, have been reported to cause
isolated deafness, DFNB 48 and Usher syndrome type‐IJ, characterized by congenital …

Discovery and development of cyclic peptide inhibitors of CIB1

VA Haberman, SR Fleming, TM Leisner… - ACS Medicinal …, 2021 - ACS Publications
Calcium and integrin binding protein 1 (CIB1) is a small, intracellular protein recently
implicated in survival and proliferation of triple-negative breast cancer (TNBC). Considering …

In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot

Y An, J Lim, M Glavatskikh, X Wang… - Nature …, 2024 - nature.com
Chemical probes are an indispensable tool for translating biological discoveries into new
therapies, though are increasingly difficult to identify since novel therapeutic targets are …

CHIP-mediated CIB1 ubiquitination regulated epithelial–mesenchymal transition and tumor metastasis in lung adenocarcinoma

Y Liu, Y Zhou, P Zhang, X Li, C Duan… - Cell Death & …, 2021 - nature.com
CIB1 is a homolog of calmodulin that regulates cell adhesion, migration, and differentiation.
It has been considered as an oncogene in many tumor cells; however, its role in lung …

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1

W Zhu, BL Gliddon, KE Jarman, PAB Moretti, T Tin… - Oncogene, 2017 - nature.com
CIB1 (calcium and integrin binding protein 1) is a small intracellular protein with numerous
interacting partners, and hence has been implicated in various cellular functions. Recent …

Tumor-infiltrated CD8+ T Cell 10-gene signature related to clear cell renal cell carcinoma prognosis

J Wang, F Huang, J Zhao, P Huang, J Tan… - Frontiers in …, 2022 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) usually affects multiple organs (eg, bone and brain),
and patient prognosis is usually poor. Although it is known that CD8+ T cell infiltration can …

Discovery and characterization of peptide inhibitors for calcium and integrin binding protein 1

AC Puhl, JW Bogart, VA Haberman… - ACS chemical …, 2020 - ACS Publications
Calcium and integrin binding protein 1 (CIB1) is an EF-hand-containing, small intracellular
protein that has recently been implicated in cancer cell survival and proliferation. In …