Double-strand DNA breaks are common events in eukaryotic cells, and there are two major
pathways for repairing them: homologous recombination (HR) and nonhomologous DNA …

Comparative genomics demonstrated that the chromosomes from bacteria and their viruses
(bacteriophages) are coevolving. This process is most evident for bacterial pathogens where …

A number of mechanisms are responsible for the resistance of spores of Bacillus species to
heat, radiation and chemicals and for spore killing by these agents. Spore resistance to wet …

DNA double-strand breaks (DSBs) are common lesions that continually threaten genomic
integrity. Failure to repair a DSB has deleterious consequences, including cell death …

Bacterial genomes are remarkably stable from one generation to the next but are plastic on
an evolutionary time scale, substantially shaped by horizontal gene transfer, genome …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

Relatively little is known about the biochemical basis of the capacity of Deinococcus
radiodurans to endure the genetic insult that results from exposure to ionizing radiation and …

SUMMARY The RecBCD enzyme of Escherichia coli is a helicase-nuclease that initiates the
repair of double-stranded DNA breaks by homologous recombination. It also degrades …

Adaptive immunity is mediated through numerous genetic and cellular processes that
generate favourable somatic variants of antigen-binding receptors under evolutionary …

Measuring biological data across time and space is critical for understanding complex
biological processes and for various biosurveillance applications. However, such data are …