Fatty acids are crucial molecules for most living beings, very well spread and conserved
across species. These molecules play a role in energy storage, cell membrane architecture …

Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

The inhibition of protein–protein interactions is a growing strategy in drug development. In
addition to structured regions, many protein loop regions are involved in protein–protein …

Animal cytoplasmic fatty acid synthase (FAS) represents a unique family of enzymes that are
classically thought to be most closely related to fungal polyketide synthase (PKS). Recently …

De novo lipogenesis is a highly regulated metabolic process, which is known to be activated
through transcriptional regulation of lipogenic genes, including fatty acid synthase (FASN) …

The modular nature of polyketide assembly lines and the significance of their products make
them prime targets for combinatorial engineering. The recently updated module boundary …

Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a 16-carbon chain
fatty acid that is the primary precursor of lipid metabolism and an important intracellular …

Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often
reduce two-carbon ketide units in de novo fatty acid and polyketide biosynthesis. Cycles of …

With the redefinition of polyketide synthase (PKS) modules, a new appreciation of their most
downstream domain, the ketosynthase (KS), is emerging. In addition to performing its well …

Lack of MHC-II is emerging as a causal factor in cancer immune evasion, and the
development of small-molecule MHC-II inducers is an unmet clinical need. Here, we …