Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Nuclear magnetic resonance (NMR) has long been instrumental in the characterization of
intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs). This …

Viruses infect all kingdoms of life; their genomes vary from DNA to RNA and in size from 2kB
to 1 MB or more. Viruses frequently employ disordered proteins, that is, protein products of …

The SARS-CoV-2 nucleocapsid (N) protein is crucial for the highly organized packaging and
transcription of the genomic RNA. Studying atomic details of the role of its intrinsically …

Novel and efficient strategies need to be developed to interfere with the SARS-CoV-2 virus.
One of the most promising pharmaceutical targets is the nucleocapsid protein (N) …

Single molecule fluorescence and nuclear magnetic resonance spectroscopy (NMR) are two
very powerful techniques for the analysis of intrinsically disordered proteins (IDPs). Both …

Viruses and their hosts are involved in an 'arms race'where they continually evolve
mechanisms to overcome each other. It has long been proposed that intrinsic disorder …

The knowledge of interactions between different molecules is undoubtedly the driving force
of all contemporary biomedical and biological sciences. Chemical biology/biological …

The microphthalmia-associated transcription factor (MITF) is a master regulator of the
melanocyte cell lineage. Aberrant MITF activity can lead to multiple malignancies including …

The study of protein dynamics using the measurement of relaxation times by NMR was
based on a set of studies in the mid-20th century that outlined theories and methods …