The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …

Protein-protein interactions (PPIs) are critical regulatory events in physiology and pathology,
and they represent an important target space for pharmacological intervention. However …

Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …

The clustered homeobox proteins play crucial roles in development, hematopoiesis, and
leukemia, yet the targets they regulate and their mechanisms of action are poorly …

Infant acute leukaemia is characterised by specific genetic rearrangements and a rapid
onset of disease shortly after birth. The vast majority of these cases bear rearranged MLL …

The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene
overexpression but is currently considered undruggable. We therefore investigated whether …

Inflammation in the bone marrow (BM) microenvironment is a constitutive component of
leukemogenesis in acute myeloid leukemia (AML). Current evidence suggests that both …

The tribbles family of genes encodes pseudokinase proteins that are highly conserved in
evolution. Instead of direct phosphorylation of target proteins, tribbles act as adaptors in …

MicroRNAs (miRNAs) have been shown to play important roles in physiological as well as
multiple malignant processes, including acute myeloid leukemia (AML). In an effort to gain …

HOX homeobox genes are important regulators of normal and malignant hematopoiesis.
Abdominal-type HOXA genes like HOXA9 are highly leukemogenic. However, little is known …