C. elegans as a model to study mitochondrial biology and disease

T Onraet, S Zuryn - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Mitochondria perform a myriad of essential functions that ensure organismal homeostasis,
including maintaining bioenergetic capacity, sensing and signalling the presence of …

Astrovirology: how viruses enhance our understanding of life in the Universe

G Trubl, KM Stedman, KF Bywaters… - International journal of …, 2023 - cambridge.org
Viruses are the most numerically abundant biological entities on Earth. As ubiquitous
replicators of molecular information and agents of community change, viruses have potent …

Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans

B Kim, AV Alcantara Jr, JH Moon, A Higashitani… - International Journal of …, 2023 - mdpi.com
While spaceflight is becoming more common than before, the hazards spaceflight and space
microgravity pose to the human body remain relatively unexplored. Astronauts experience …

Spaceflight Induces Strength Decline in Caenorhabditis elegans

P Soni, H Edwards, T Anupom, M Rahman… - Cells, 2023 - mdpi.com
Background: Understanding and countering the well-established negative health
consequences of spaceflight remains a primary challenge preventing safe deep space …

Microgravity alters the expressions of DNA repair genes and their regulatory miRNAs in space-flown Caenorhabditis elegans

L Zhao, G Zhang, A Tang, B Huang, D Mi - Life Sciences in Space Research, 2023 - Elsevier
During spaceflight, multiple unique hazardous factors, particularly microgravity and space
radiation, can induce different types of DNA damage, which pose a constant threat to …

Caenorhabditis elegans in microgravity: An omics perspective

A Scott, CRG Willis, M Muratani, A Higashitani… - Iscience, 2023 - cell.com
The application of omics to study Caenorhabditis elegans (C. elegans) in the context of
spaceflight is increasing, illuminating the wide-ranging biological impacts of spaceflight on …

Mitochondrial Extracellular Vesicles (mitoEVs): emerging mediators of cell-to-cell communication in health, aging and age-related diseases.

R Iorio, S Petricca, G Di Emidio, S Falone… - Ageing Research …, 2024 - Elsevier
Mitochondria are metabolic and signalling hubs that integrate a plethora of interconnected
processes to maintain cell homeostasis. They are also dormant mediators of inflammation …

Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in …

G Zhang, L Zhao, Z Li, Y Sun - Life Sciences in Space Research, 2025 - Elsevier
The space environment presents unique stressors, such as microgravity and space
radiation, which can induce molecular and physiological changes in living organisms. To …

Exploiting the Unique Biology of Caenorhabditis elegans to Launch Neurodegeneration Studies in Space

T Itkin, K Unger, Y Barak, A Yovel, L Stekolshchik… - Astrobiology, 2024 - liebertpub.com
The 21st century is likely to be the first century in which large-scale short-and long-term
space missions become common. Accordingly, an ever-increasing body of research is …

Cytoskeletal tensegrity in microgravity

J Gardiner - Life, 2021 - mdpi.com
In order for Man to venture further into Space he will have to adapt to its conditions, including
microgravity. Life as we know it has evolved on Earth with a substantial gravitational field. If …