Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications

G Murdaca, A Tonacci, S Negrini, M Greco, M Borro… - Autoimmunity …, 2019 - Elsevier
Vitamin D plays a key role in in calcium homeostasis and, thus, provides an important
support in bone growth by aiding in the mineralization of the collagen matrix. However …

Vitamin D and multiple sclerosis: a comprehensive review

MB Sintzel, M Rametta, AT Reder - Neurology and therapy, 2018 - Springer
Numerous observational studies have suggested that there is a correlation between the
level of serum vitamin D and MS risk and disease activity. To explore this hypothesis, a …

Modulation of inflammatory and immune responses by vitamin D

F Colotta, B Jansson, F Bonelli - Journal of autoimmunity, 2017 - Elsevier
Vitamin D (VitD) is a prohormone most noted for the regulation of calcium and phosphate
levels in circulation, and thus of bone metabolism. Inflammatory and immune cells not only …

Vitamin D as an early predictor of multiple sclerosis activity and progression

A Ascherio, KL Munger, R White, K Köchert… - JAMA …, 2014 - jamanetwork.com
Importance It remains unclear whether vitamin D insufficiency, which is common in
individuals with multiple sclerosis (MS), has an adverse effect on MS outcomes. Objectives …

Infections and autoimmunity—the Immune System and vitamin D: a systematic review

SJ Wimalawansa - Nutrients, 2023 - mdpi.com
Both 25-autoimmunity and (25 (OH) D: calcifediol) and its active form, 1, 25-dihydroxyvitamin
D (1, 25 (OH) 2D: calcitriol), play critical roles in protecting humans from invasive pathogens …

Vitamin D in neurological diseases: a rationale for a pathogenic impact

R Moretti, ME Morelli, P Caruso - International journal of molecular …, 2018 - mdpi.com
It is widely known that vitamin D receptors have been found in neurons and glial cells, and
their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical …

Body fluid biomarkers in multiple sclerosis

M Comabella, X Montalban - The Lancet Neurology, 2014 - thelancet.com
Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological
disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of …

Safety and immunologic effects of high-vs low-dose cholecalciferol in multiple sclerosis

ES Sotirchos, P Bhargava, C Eckstein, K Van Haren… - Neurology, 2016 - AAN Enterprises
Objective: To study the safety profile and characterize the immunologic effects of high-vs low-
dose cholecalciferol supplementation in patients with multiple sclerosis (MS). Methods: In …

Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

P Ostkamp, A Salmen, B Pignolet… - Proceedings of the …, 2021 - National Acad Sciences
Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study
assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and …

Vitamin D and autoimmunity

Y Rosen, J Daich, I Soliman, E Brathwaite… - Scandinavian journal …, 2016 - Taylor & Francis
Objectives: To review and evaluate the role of vitamin D in autoimmune diseases based on
current studies. Method: We searched PubMed using keywords such as 'vitamin …