Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …

Patients heterozygous for germline CBL loss-of-function (LOF) variants can develop myeloid
malignancy, autoinflammation, or both, if some or all of their leukocytes become …

A major reason for the high mortality of patients with bladder cancer (BC) is that
chemotherapy and surgery are only effective for very limited patients. Thus, developing …

Simple Summary CBL mutations are progressively being described as involved in different
clinical manifestations. Somatic CBL mutations can be found in different type of cancer. The …

Despite distinct clinical entities, the myeloproliferative neoplasms (MPN) share
morphological similarities, propensity to thrombotic events and leukemic evolution, and a …

The endocytic trafficking pathway is a highly organized cellular program responsible for the
regulation of membrane components and uptake of extracellular substances. Molecules …

Context Echinacoside (ECH) is a natural anti-cancer compound and is of great value in
cancer treatment. However, the mechanism underlying this effect on breast cancer (BC) was …

Background Polycystic ovary syndrome (PCOS) is a hormonal disorder characterized by
hyperandrogenism, ovulatory dysfunction, and insulin resistance. Evidence suggests that …

Simple Summary Juvenile myelomonocytic leukemia (JMML) is a rare pediatric
myelodysplastic/myeloproliferative neoplasm characterized by the constitutive activation of …