Stem cell therapies for treating diabetes: progress and remaining challenges
Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …
diabetes research and therapy. While whole-organ and islet transplantation have become …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas
Extracellular matrix (ECM) plays an important developmental role by regulating cell
behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained …
behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained …
The journey of islet cell transplantation and future development
A Gamble, AR Pepper, A Bruni, AMJ Shapiro - Islets, 2018 - Taylor & Francis
Intraportal islet transplantation has proven to be efficacious in preventing severe
hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes …
hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes …
Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering
Approximately 285 million people worldwide suffer from diabetes, with insulin
supplementation as the most common treatment measure. Regenerative medicine …
supplementation as the most common treatment measure. Regenerative medicine …
Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges
IBB Silva, CH Kimura, VP Colantoni… - Stem cell research & …, 2022 - Springer
Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune
destruction of insulin-producing β-pancreatic cells. Although many advances have been …
destruction of insulin-producing β-pancreatic cells. Although many advances have been …
Organoid microphysiological system preserves pancreatic islet function within 3D matrix
Three-dimensional (3D) multicellular organoids recapitulate the native complexities of
human tissue better than traditional cellular monolayers. As organoids are insufficiently …
human tissue better than traditional cellular monolayers. As organoids are insufficiently …
Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets
Extracellular matrix (ECM) molecules are responsible for structural and biochemical support,
as well as for regulation of molecular signalling and tissue repair in many organ structures …
as well as for regulation of molecular signalling and tissue repair in many organ structures …
Looking into the future: toward advanced 3D biomaterials for stem‐Cell‐based regenerative medicine
Z Liu, M Tang, J Zhao, R Chai, J Kang - Advanced Materials, 2018 - Wiley Online Library
Stem‐cell‐based therapies have the potential to provide novel solutions for the treatment of
a variety of diseases, but the main obstacles to such therapies lie in the uncontrolled …
a variety of diseases, but the main obstacles to such therapies lie in the uncontrolled …
Signals in the pancreatic islet microenvironment influence β‐cell proliferation
KI Aamodt, AC Powers - Diabetes, Obesity and Metabolism, 2017 - Wiley Online Library
The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …