DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Background Targeting PLK1 has recently been proven as a viable therapeutic strategy
against oesophageal squamous cell carcinom (ESCC). Therefore, this study aimed to …

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …

In response to diverse genotoxic stresses, cells activate DNA damage checkpoint pathways
to protect genomic integrity and promote survival of the organism. Depending on DNA …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …

Despite all the other cells that have the potential to prevent cancer development and
metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin …

In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and
instead initiate DNA repair. Here, we show that, in response to genotoxic stress in G2, the …

The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to
cell division known as the cell cycle. Not only does ubiquitin-mediated proteolysis constitute …

14-3-3 proteins play critical roles in the regulation of cell fate through phospho-dependent
binding to a large number of intracellular proteins that are targeted by various classes of …