[HTML][HTML] Immunity to the respiratory pathogen Bordetella pertussis
Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants
and children, and also infects adults. Studies in murine models have shown that innate …
and children, and also infects adults. Studies in murine models have shown that innate …
[HTML][HTML] Biologic functions of the IFN‐γ receptors
G Tau, P Rothman - Allergy, 1999 - ncbi.nlm.nih.gov
Interferon-gamma (IFN-c) is a cytokine that plays an important role in inducing and
modulating an array of immune responses. Cellular responses to IFN-c are mediated by its …
modulating an array of immune responses. Cellular responses to IFN-c are mediated by its …
[HTML][HTML] Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis …
PJ Ross, CE Sutton, S Higgins, AC Allen… - PLoS …, 2013 - journals.plos.org
Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite
the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa …
the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa …
Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel …
P McGuirk, C McCann, KHG Mills - The Journal of experimental …, 2002 - rupress.org
Antigen-specific T helper type 1 (Th1) cells mediate protective immunity against a range of
infectious diseases, including that caused by Bordetella pertussis. Distinct T cell subtypes …
infectious diseases, including that caused by Bordetella pertussis. Distinct T cell subtypes …
Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung
Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain the
immunoglobulins (Ig) G and secretory IgA (sIgA) that function together in host defense …
immunoglobulins (Ig) G and secretory IgA (sIgA) that function together in host defense …
Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with Bordetella pertussis
MM Wilk, A Misiak, RM McManus, AC Allen… - The Journal of …, 2017 - journals.aai.org
Th1 and Th17 cells have an established role in protective immunity to Bordetella pertussis,
but this evidence is based largely on peripheral T cells. There is emerging evidence that …
but this evidence is based largely on peripheral T cells. There is emerging evidence that …
TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells
SC Higgins, AG Jarnicki, EC Lavelle… - The Journal of …, 2006 - journals.aai.org
Whole cell pertussis vaccines (Pw) induce Th1 responses and protect against Bordetella
pertussis infection, whereas pertussis acellular vaccines (Pa) induce Ab and Th2-biased …
pertussis infection, whereas pertussis acellular vaccines (Pa) induce Ab and Th2-biased …
Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation
Mesenchymal stem cells (MSC) possess a wide range of immunosuppressive functions.
Among these is the ability to inhibit CD4+ T cell proliferation. Dendritic cells (DC) play a role …
Among these is the ability to inhibit CD4+ T cell proliferation. Dendritic cells (DC) play a role …
[HTML][HTML] Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL …
Current acellular pertussis (aP) vaccines induce strong antibody and Th2 responses but fail
to protect against nasal colonization and transmission of Bordetella pertussis. Furthermore …
to protect against nasal colonization and transmission of Bordetella pertussis. Furthermore …
[HTML][HTML] IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils
Understanding the mechanism of protective immunity in the nasal mucosae is central to the
design of more effective vaccines that prevent nasal infection and transmission of Bordetella …
design of more effective vaccines that prevent nasal infection and transmission of Bordetella …