Large-scale comparative assessment of computational predictors for lysine post-translational modification sites
Lysine post-translational modifications (PTMs) play a crucial role in regulating diverse
functions and biological processes of proteins. However, because of the large volumes of …
functions and biological processes of proteins. However, because of the large volumes of …
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that
regulate nuclear cellular processes. Here we used an augmented K0–SUMO proteomics …
regulate nuclear cellular processes. Here we used an augmented K0–SUMO proteomics …
Paradoxes of cellular SUMOylation regulation: a role of biomolecular condensates?
X Cheng, W Yang, W Lin, F Mei, G Schulte - Pharmacological Reviews, 2023 - Elsevier
Protein SUMOylation is a major post-translational modification essential for maintaining
cellular homeostasis. SUMOylation has long been associated with stress responses as a …
cellular homeostasis. SUMOylation has long been associated with stress responses as a …
dForml (KNN)-PseAAC: Detecting formylation sites from protein sequences using K-nearest neighbor algorithm via Chou's 5-step rule and pseudo components
Formylation is a type of post-translational modification that can occur on lysine sites, which
plays an irreplaceable role in organism. To better understand the mechanism, it is necessary …
plays an irreplaceable role in organism. To better understand the mechanism, it is necessary …
SUMOgo: Prediction of sumoylation sites on lysines by motif screening models and the effects of various post-translational modifications
Most modern tools used to predict sites of small ubiquitin-like modifier (SUMO) binding
(referred to as SUMOylation) use algorithms, chemical features of the protein, and …
(referred to as SUMOylation) use algorithms, chemical features of the protein, and …
The impact of the C-terminal region on the interaction of topoisomerase II alpha with mitotic chromatin
M Antoniou-Kourounioti, ML Mimmack… - International journal of …, 2019 - mdpi.com
Type II topoisomerase enzymes are essential for resolving DNA topology problems arising
through various aspects of DNA metabolism. In vertebrates two isoforms are present, one of …
through various aspects of DNA metabolism. In vertebrates two isoforms are present, one of …
Feature extractions for computationally predicting protein post-translational modifications
G Huang, J Li - Current Bioinformatics, 2018 - ingentaconnect.com
Background: Post-translational modifications (PTMs) are a key regulating mechanism in the
cellular process. It is of importance to quickly and accurately identify PTMs. Both next …
cellular process. It is of importance to quickly and accurately identify PTMs. Both next …
HseSUMO: Sumoylation site prediction using half-sphere exposures of amino acids residues
Background Post-translational modifications are viewed as an important mechanism for
controlling protein function and are believed to be involved in multiple important diseases …
controlling protein function and are believed to be involved in multiple important diseases …
SumSec: accurate prediction of sumoylation sites using predicted secondary structure
Post Translational Modification (PTM) is defined as the modification of amino acids along the
protein sequences after the translation process. These modifications significantly impact on …
protein sequences after the translation process. These modifications significantly impact on …
SumoPred-PLM: human SUMOylation and SUMO2/3 sites Prediction using Pre-trained Protein Language Model
AV Palacios, P Acharya, AS Peidl… - NAR Genomics and …, 2024 - academic.oup.com
SUMOylation is an essential post-translational modification system with the ability to
regulate nearly all aspects of cellular physiology. Three major paralogues SUMO1, SUMO2 …
regulate nearly all aspects of cellular physiology. Three major paralogues SUMO1, SUMO2 …