Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
characterized by poor treatment response and low survival time. The current clinical …

Tumor-associated macrophages (TAMs) are pivotal in cancer progression, influencing tumor
growth, angiogenesis, and immune evasion. This review explores the spatial and temporal …

Macrophages are important components of the immune system. Mature macrophages can
be recruited to tumor microenvironment that affect tumor cell proliferation, invasion and …

Osteopontin (OPN) is a multifunctional phosphorylated protein. It is widely involved in solid
tumor progression, such as intensification of macrophage recruitment, inhibition of T-cell …

The secretory properties of cancer-associated fibroblasts (CAFs) play predominant roles in
shaping a pro-metastatic tumor microenvironment. The present study demonstrated that …

Macrophages are heterogeneous cells that play multifaceted roles in cancer progression
and metastasis. However, the phenotypic diversity of tumor-associated macrophages …

Breast cancer (BC) represents a paradigm of heterogeneity, manifesting as a spectrum of
molecular subtypes with divergent clinical trajectories. It is fundamentally characterized by …

Metalloproteinases (MPs) is a large family of proteinases with metal ions in their active
centers. According to the different domains metalloproteinases can be divided into a variety …