The extracellular matrix as a multitasking player in disease
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer
M Walraven, B Hinz - Matrix Biology, 2018 - Elsevier
Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular
matrix (ECM) and represents the final stage of several life-threatening diseases. The …
matrix (ECM) and represents the final stage of several life-threatening diseases. The …
[HTML][HTML] Mechanosensitive Piezo1 channels mediate renal fibrosis
X Zhao, Y Kong, B Liang, J Xu, Y Lin, N Zhou, J Li… - JCI insight, 2022 - ncbi.nlm.nih.gov
Kidney fibrosis is the final common pathway of progressive kidney diseases, the underlying
mechanisms of which are not fully understood. The purpose of the current study is to …
mechanisms of which are not fully understood. The purpose of the current study is to …
Basement membrane stiffness determines metastases formation
The basement membrane (BM) is a special type of extracellular matrix and presents the
major barrier cancer cells have to overcome multiple times to form metastases. Here we …
major barrier cancer cells have to overcome multiple times to form metastases. Here we …
DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration
Migration through micron-size constrictions has been seen to rupture the nucleus, release
nuclear-localized GFP, and cause localized accumulations of ectopic 53BP1—a DNA repair …
nuclear-localized GFP, and cause localized accumulations of ectopic 53BP1—a DNA repair …
Cell softness regulates tumorigenicity and stemness of cancer cells
Identifying and sorting highly tumorigenic and metastatic tumor cells from a heterogeneous
cell population is a daunting challenge. Here, we show that microfluidic devices can be used …
cell population is a daunting challenge. Here, we show that microfluidic devices can be used …
An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation
Integrins are membrane receptors that mediate cell adhesion and mechanosensing. The
structure–function relationship of integrins remains incompletely understood, despite the …
structure–function relationship of integrins remains incompletely understood, despite the …
TRPV4 plays a role in matrix stiffness-induced macrophage polarization
Phenotypic polarization of macrophages is deemed essential in innate immunity and various
pathophysiological conditions. We have now determined key aspects of the molecular …
pathophysiological conditions. We have now determined key aspects of the molecular …
Maintaining proteostasis under mechanical stress
Cell survival, tissue integrity and organismal health depend on the ability to maintain
functional protein networks even under conditions that threaten protein integrity. Protection …
functional protein networks even under conditions that threaten protein integrity. Protection …
[HTML][HTML] Mechanical forces: The missing link between idiopathic pulmonary fibrosis and lung cancer
C Wang, J Yang - European Journal of Cell Biology, 2022 - Elsevier
Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer
compared with the general population. The morbidity of lung cancer in IPF patient ranges …
compared with the general population. The morbidity of lung cancer in IPF patient ranges …