Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning
Background—Ischemic preconditioning provides strong cardioprotection from ischemia, but
its molecular mechanisms remain unknown. Convincing evidence confirms a central role of …
its molecular mechanisms remain unknown. Convincing evidence confirms a central role of …
Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1α
Injured peripheral neurons successfully activate a proregenerative transcriptional program
to enable axon regeneration and functional recovery. How transcriptional regulators …
to enable axon regeneration and functional recovery. How transcriptional regulators …
CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteosarcoma microenvironment
Chemokines modulate angiogenesis and metastasis that dictate cancer development in
tumor microenvironment. Osteosarcoma is the most frequent bone tumor and is …
tumor microenvironment. Osteosarcoma is the most frequent bone tumor and is …
[HTML][HTML] Inhibition of protein kinase C δ attenuates blood-retinal barrier breakdown in diabetic retinopathy
JH Kim, JH Kim, HO Jun, YS Yu, KW Kim - The American journal of …, 2010 - Elsevier
Vision loss in diabetic retinopathy is due to macular edema characterized by increased
vascular permeability, which involves phosphorylation associated with activation of protein …
vascular permeability, which involves phosphorylation associated with activation of protein …
Impact of extrinsic and intrinsic hypoxia on catecholamine biosynthesis in absence or presence of Hif2α in pheochromocytoma cells
N Bechmann, I Poser, V Seifert, C Greunke, M Ullrich… - Cancers, 2019 - mdpi.com
Pheochromocytomas and paragangliomas (PPGLs) with activated pseudohypoxic pathways
are associated with an immature catecholamine phenotype and carry a higher risk for …
are associated with an immature catecholamine phenotype and carry a higher risk for …
A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells
T Masaki, T Kojima, T Okabayashi… - Molecular biology of …, 2011 - Am Soc Cell Biol
Respiratory syncytial virus (RSV) is the major cause of bronchitis, asthma, and severe lower
respiratory tract disease in infants and young children. The airway epithelium, which has a …
respiratory tract disease in infants and young children. The airway epithelium, which has a …
Hypoxia-mediated complement 1q binding protein regulates metastasis and chemoresistance in triple-negative breast cancer and modulates the PKC-NF-κB-VCAM-1 …
H Wu, Y Chu, S Sun, G Li, S Xu, X Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
Objectives Complement 1q binding protein (C1QBP/HABP1/p32/gC1qR) has been found to
be overexpressed in triple-negative breast cancer (TNBC). However, the underlying …
be overexpressed in triple-negative breast cancer (TNBC). However, the underlying …
Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells
EC Finger, L Castellini, EB Rankin… - Proceedings of the …, 2015 - National Acad Sciences
Scaffold proteins are critical hubs within cells that have the ability to modulate upstream
signaling molecules and their downstream effectors to fine-tune biological responses …
signaling molecules and their downstream effectors to fine-tune biological responses …
Maslinic acid alleviates ischemia/reperfusion-induced inflammation by downregulation of NFκB-mediated adhesion molecule expression
E Ampofo, JJ Berg, MD Menger, MW Laschke - Scientific Reports, 2019 - nature.com
Abstract Ischemia/reperfusion (I/R)-induced inflammation is associated with enhanced
leukocyte rolling, adhesion and transmigration within the microcirculation. These steps are …
leukocyte rolling, adhesion and transmigration within the microcirculation. These steps are …
Potentials of PKC in cancer progression and anticancer drug development
SJ Deka, V Trivedi - Current drug discovery technologies, 2019 - ingentaconnect.com
PKC is a family of serine-threonine kinases which play crucial roles in the regulation of
important signal transduction pathways in mammalian cell-biology. These enzymes are …
important signal transduction pathways in mammalian cell-biology. These enzymes are …