Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome that is inherited in an
autosomal dominant pattern, is continuing to raise great interest for endocrinology …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …

Summary The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is
mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally …

Pancreatic endocrine tumors (PETs) have long fascinated clini-cians, because some can
release biologically active hormones that cause distinct syndromes and provide important …

The cellular function of the menin tumor suppressor protein, product of the MEN1 gene
mutated in familial multiple endocrine neoplasia type 1, has not been defined. We now show …

Menin displays the unique ability to either promote oncogenic function in the hematopoietic
lineage or suppress tumorigenesis in the endocrine lineage; however, its molecular …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

Histone modifications influence the interactions of transcriptional regulators with chromatin.
Studies in embryos and embryonic stem (ES) cells have uncovered histone modification …

The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple
endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor …