Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges
DN Patel, L Li, CL Kee, X Ge, MY Low… - Journal of pharmaceutical …, 2014 - Elsevier
The popularity of phosphodiesterase type 5 (PDE-5) enzyme inhibitors for the treatment of
erectile dysfunction has led to the increase in prevalence of illicit sexual performance …
erectile dysfunction has led to the increase in prevalence of illicit sexual performance …
A review of synthetic phosphodiesterase type 5 inhibitors (PDE-5i) found as adulterants in dietary supplements
CL Kee, X Ge, V Gilard, M Malet-Martino… - Journal of pharmaceutical …, 2018 - Elsevier
To date, there are 80 synthetic PDE-5i found as adulterants in dietary supplements.
Analogues of sildenafil remain as the top list with 50 (62%) and are followed by analogues …
Analogues of sildenafil remain as the top list with 50 (62%) and are followed by analogues …
Rapid determination of sildenafil and its analogues in dietary supplements using gas chromatography–triple quadrupole mass spectrometry
SU Mokhtar, ST Chin, CL Kee, MY Low… - … of Pharmaceutical and …, 2016 - Elsevier
Application of gas chromatography–triple quadrupole mass spectrometry for identification,
confirmation and quantification of 6 phosphodiesterase-5 (PDE-5) inhibitors (sildenafil …
confirmation and quantification of 6 phosphodiesterase-5 (PDE-5) inhibitors (sildenafil …
Detection of sildenafil adulterated in herbal products using thin layer chromatography combined with surface enhanced Raman spectroscopy:“Double coffee-ring …
Sildenafil is an inhibitor of the phosphodiesterase type 5 which is commonly adulterated in
herbal health products. In this study, a rapid, sensitive and selective method using thin layer …
herbal health products. In this study, a rapid, sensitive and selective method using thin layer …
Reliable screening and classification of phosphodiesterase type 5 inhibitors in dietary supplements using gas chromatography/mass spectrometry combined with …
W Lee, HJ Kim, ME Lee, BH Kim, S Park, JH Lee… - … of Chromatography A, 2020 - Elsevier
Illegal dietary supplements adulterated with phosphodiesterase type 5 inhibitors (PDE-5i)
are increasingly widely distributed through internet markets and underground routes. For …
are increasingly widely distributed through internet markets and underground routes. For …
A Comprehensive Review on Analytical techniques for determination of sex stimulants, PDE5 inhibitors in different matrices with Special Focus on the …
Erectile dysfunction (ED) is one of the most common chronic diseases affecting men and its
incidence increases with aging. Due to its substantial influence on the quality of life …
incidence increases with aging. Due to its substantial influence on the quality of life …
Magnetic solid-phase extraction based on methylcellulose coated-Fe3O4–SiO2–phenyl for HPLC–DAD analysis of sildenafil and its metabolite in biological samples
M Tang, Q Wang, M Jiang, L Xu, ZG Shi, T Zhang, Y Liu - Talanta, 2014 - Elsevier
In the present study, magnetic nanoparticles (MNPs) with phenyl functionalized core and a
hydrophilic methylcellulose coating were synthesized. The functionalized MNPs showed …
hydrophilic methylcellulose coating were synthesized. The functionalized MNPs showed …
Determination of the illegal adulteration of natural healthcare products with chemical drugs using surface-enhanced Raman scattering
J Wu, L Zhang, X Bu, P Li, B Zhao, Y Tian - Analyst, 2018 - pubs.rsc.org
The illegal adulteration of natural healthcare products with chemical drugs can result in
serious health risks for consumers. Thus there is an urgent need for a fast and precise …
serious health risks for consumers. Thus there is an urgent need for a fast and precise …
Adulterated and counterfeit male enhancement nutraceuticals and dietary supplements pose a real threat to the management of erectile dysfunction: A global …
F ElAmrawy, G ElAgouri, O Elnoweam… - Journal of dietary …, 2016 - Taylor & Francis
Erectile dysfunction prevalence globally is noticeably high. This is accompanied by an
increase in the use of nutraceuticals for male enhancement. However, the global market is …
increase in the use of nutraceuticals for male enhancement. However, the global market is …
Rapid detection of six phosphodiesterase type 5 enzyme inhibitors in healthcare products using thin‐layer chromatography and surface enhanced Raman …
X Hu, G Fang, A Han, Y Fu, R Tong… - Journal of separation …, 2017 - Wiley Online Library
A novel facile method for the detection of the phosphodiesterase type 5 enzyme inhibitors
added illegally into health products was established using thin‐layer chromatography and …
added illegally into health products was established using thin‐layer chromatography and …