Early life nutrition and mental health: the role of DNA methylation

RA Bekdash - Nutrients, 2021 - mdpi.com
Does the quality of our diet during early life impact our long-term mental health?
Accumulating evidence suggests that nutrition interacts with our genes and that there is a …

[HTML][HTML] Integrating molecular perspectives: strategies for comprehensive multi-omics integrative data analysis and machine learning applications in transcriptomics …

PHG Sanches, NC de Melo, AM Porcari… - Biology, 2024 - mdpi.com
Simple Summary Recent high-throughput technologies such as transcriptomics, proteomics,
and metabolomics have allowed progress in understanding biological systems at different …

Placental methylome reveals a 22q13. 33 brain regulatory gene locus associated with autism

Y Zhu, JA Gomez, BI Laufer, CE Mordaunt, JS Mouat… - Genome biology, 2022 - Springer
Background Autism spectrum disorder (ASD) involves complex genetics interacting with the
perinatal environment, complicating the discovery of common genetic risk. The epigenetic …

Exploring HLA-C methylation patterns and nutritional status in Kichwa mothers and infants from Tena, Ecuador

E Velastegui, IB Falconí, VI Garcia, G Munizaga… - Frontiers in …, 2024 - frontiersin.org
Environment and lifestyle can affect the epigenome passed down from generation to
generation. A mother's nutrition can impact the methylation levels of her offspring's …

Biological implications of genetic variations in autism spectrum disorders from genomics studies

Y Zhang, X Liu, R Guo, W Xu, Q Guo, C Hao… - Bioscience …, 2021 - portlandpress.com
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental condition
characterized by atypical social interaction and communication together with repetitive …

Autism spectrum disorder: Pathogenesis, biomarker, and intervention therapy

H Zhuang, Z Liang, G Ma, A Qureshi, X Ran… - MedComm, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder. The
heterogeneity of ASD poses great challenges for its research and clinical translation. On the …

Maternal plasma metabolic profile demarcates a role for neuroinflammation in non-typical development of children

RJ Schmidt, D Liang, SA Busgang, P Curtin, C Giulivi - Metabolites, 2021 - mdpi.com
Maternal and cord plasma metabolomics were used to elucidate biological pathways
associated with increased diagnosis risk for autism spectrum disorders (ASD). Metabolome …

Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues

M Daneshi, PP Borowicz, MR Hirchert… - Frontiers in Veterinary …, 2024 - frontiersin.org
Introduction Maternal nutrition during pregnancy critically influences offspring development
and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may …

Differential One-Carbon Metabolites among Children with Autism Spectrum Disorder: A Case-Control Study

T Wang, W He, Y Chen, Y Gou, Y Ma, X Du… - The Journal of …, 2024 - Elsevier
Background Driven by the complex multifactorial etiopathogenesis of autism spectrum
disorder (ASD), a growing interest surrounds the disturbance in folate-dependent one …

Integrative approaches to m6A and m5C RNA modifications in autism spectrum disorder revealing potential causal variants

SM Jan, A Fahira, ESG Hassan, AS Abdelhameed… - Mammalian …, 2024 - Springer
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that currently
affects approximately 1–2% of the global population. Genome-wide studies have identified …