Ancient DNA analysis

L Orlando, R Allaby, P Skoglund… - Nature reviews …, 2021 - nature.com
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

[HTML][HTML] The what, how and why of archaeological coprolite analysis

LM Shillito, JC Blong, EJ Green, EN van Asperen - Earth-Science Reviews, 2020 - Elsevier
Coprolites are a highly informative but still underutilized proxy for understanding past
environments, palaeodiets, and ancient human health. Here we provide a critical review of …

[HTML][HTML] Reconstruction of ancient microbial genomes from the human gut

MC Wibowo, Z Yang, M Borry, A Hübner, KD Huang… - Nature, 2021 - nature.com
Loss of gut microbial diversity,,,,–in industrial populations is associated with chronic
diseases, underscoring the importance of studying our ancestral gut microbiome. However …

Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions

A Blanco-Míguez, EJC Gálvez, E Pasolli, F De Filippis… - Cell host & …, 2023 - cell.com
Summary The Segatella copri (formerly Prevotella copri) complex (ScC) comprises taxa that
are key members of the human gut microbiome. It was previously described to contain four …

Metagenomic insight into the global dissemination of the antibiotic resistome

Q Zhang, N Xu, C Lei, B Chen, T Wang, Y Ma… - Advanced …, 2023 - Wiley Online Library
The global crisis in antimicrobial resistance continues to grow. Estimating the risks of
antibiotic resistance transmission across habitats is hindered by the lack of data on mobility …

Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

E Piperni, LH Nguyen, P Manghi, H Kim, E Pasolli… - Cell, 2024 - cell.com
Diet impacts human health, influencing body adiposity and the risk of developing
cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but …

Reproducible, portable, and efficient ancient genome reconstruction with nf-core/eager

JAF Yates, TC Lamnidis, M Borry, AA Valtueña… - PeerJ, 2021 - peerj.com
The broadening utilisation of ancient DNA to address archaeological, palaeontological, and
biological questions is resulting in a rising diversity in the size of laboratories and scale of …

Hallstatt miners consumed blue cheese and beer during the Iron Age and retained a non-Westernized gut microbiome until the Baroque period

F Maixner, MS Sarhan, KD Huang, A Tett… - Current Biology, 2021 - cell.com
We subjected human paleofeces dating from the Bronze Age to the Baroque period (18 th
century AD) to in-depth microscopic, metagenomic, and proteomic analyses. The paleofeces …

Edible flora in pre-Columbian Caribbean coprolites: Expected and unexpected data

J Reynoso-García, TM Santiago-Rodriguez… - Plos one, 2023 - journals.plos.org
Coprolites, or mummified feces, are valuable sources of information on ancient cultures as
they contain ancient DNA (aDNA). In this study, we analyzed ancient plant DNA isolated …

PyDamage: automated ancient damage identification and estimation for contigs in ancient DNA de novo assembly

M Borry, A Hübner, AB Rohrlach, C Warinner - PeerJ, 2021 - peerj.com
DNA de novo assembly can be used to reconstruct longer stretches of DNA (contigs),
including genes and even genomes, from short DNA sequencing reads. Applying this …