An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA
function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes …

Here, we present an update of the CHARMM27 all‐atom additive force field for nucleic acids
that improves the treatment of RNA molecules. The original CHARMM27 force field …

In this review, we discuss the experimental static deuteron NMR techniques and
computational approaches most useful for the investigation of side-chain dynamics in …

Multidimensional heteronuclear NMR approaches can provide nearly complete sequential
signal assignments of isotopically enriched biomolecules. The availability of assignments …

Typically, protein dynamics involve a complex hierarchy of motions occurring on different
time scales between conformations separated by a range of different energy barriers. NMR …

Base pairs are fundamental building blocks of RNA. The base pairs of low stability are often
critical in RNA functions. Here, we develop a solid-state NMR-based water-RNA exchange …

We conducted a detailed investigation of the dynamics of two phenylalanine side chains in
the hydrophobic core of the villin headpiece subdomain protein (HP36) in the hydrated …

Viruses, relatively simple pathogens, are able to replicate in many living organisms and to
adapt to various environments. Conventional atomic-resolution structural biology …

Many RNAs undergo large conformational changes in response to the binding of proteins
and small molecules. However, when RNA functional dynamics occur in the nanosecond …

We investigated site-specific dynamics of key methyl groups in the hydrophobic core of
chicken villin headpiece subdomain (HP36) over the temperature range between 298 and …