Senescence and aging: Causes, consequences, and therapeutic avenues
D McHugh, J Gil - Journal of Cell Biology, 2018 - rupress.org
Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and
neurodegenerative disorders. Although we are far from understanding the biological basis of …
neurodegenerative disorders. Although we are far from understanding the biological basis of …
STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement
Making sense of rapidly evolving evidence on genetic associations is crucial to making
genuine advances in human genomics and the eventual integration of this information in the …
genuine advances in human genomics and the eventual integration of this information in the …
Genetic variants associated with Lp (a) lipoprotein level and coronary disease
R Clarke, JF Peden, JC Hopewell… - … England Journal of …, 2009 - Mass Medical Soc
Background An increased level of Lp (a) lipoprotein has been identified as a risk factor for
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …
Epigenetics: a molecular link between environmental factors and type 2 diabetes
Although obesity, reduced physical activity, and aging increase susceptibility to type 2
diabetes, many people exposed to these risk factors do not develop the disease. Recent …
diabetes, many people exposed to these risk factors do not develop the disease. Recent …
ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
ABSTRACT A large noncoding RNA called ANRIL (for antisense noncoding RNA in the
INK4 locus) has been identified within the p15/CDKN2B‐p16/CDKN2A‐p14/ARF gene …
INK4 locus) has been identified within the p15/CDKN2B‐p16/CDKN2A‐p14/ARF gene …
Genetics insights in the relationship between type 2 diabetes and coronary heart disease
MO Goodarzi, JI Rotter - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus is a major risk factor for coronary heart disease (CHD). The major form of
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …
IGF2BP2/IMP2-deficient mice resist obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding mitochondrial proteins
N Dai, L Zhao, D Wrighting, D Krämer, A Majithia… - Cell metabolism, 2015 - cell.com
Although variants in the IGF2BP2/IMP2 gene confer risk for type 2 diabetes, IMP2, an RNA
binding protein, is not known to regulate metabolism. Imp2−/− mice gain less lean mass after …
binding protein, is not known to regulate metabolism. Imp2−/− mice gain less lean mass after …
Genome-wide association studies in type 2 diabetes
MI McCarthy, E Zeggini - Current diabetes reports, 2009 - Springer
Despite numerous candidate gene and linkage studies, the field of type 2 diabetes (T2D)
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …
Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population
YC Chang, PH Liu, WJ Lee, TJ Chang, YD Jiang… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Genetic variants in the fat mass and obesity-associated (FTO) gene have
been linked with obesity and type 2 diabetes in European populations. We aimed to test the …
been linked with obesity and type 2 diabetes in European populations. We aimed to test the …
Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a …
OBJECTIVE—Genome-wide association studies have identified common variants in
CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, HHEX/IDE, EXT2, and LOC387761 loci that …
CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, HHEX/IDE, EXT2, and LOC387761 loci that …