Current status of N-, O-, S-heterocycles as potential alkaline phosphatase inhibitors: a medicinal chemistry overview
Heterocycles are a class of compounds that have been found to be potent inhibitors of
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
Modified optoelectronic parameters by end-group engineering of ADA type non-fullerene-based small symmetric acceptors constituting IBDT core for high …
End-chain exploration of Non-Fullerene Acceptors is an efficient approach to amplify the
photovoltaic properties of organic solar cells (OSCs). This green energy technology has …
photovoltaic properties of organic solar cells (OSCs). This green energy technology has …
Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review
Acyl thioureas represent a privileged moiety with vast potential applicability across diverse
fields, making them the subject of extensive research efforts. The inherent flexibility of …
fields, making them the subject of extensive research efforts. The inherent flexibility of …
Analysis of 1-aroyl-3-[3-chloro-2-methylphenyl] thiourea hybrids as potent urease inhibitors: synthesis, biochemical evaluation and computational approach
Urease is an amidohydrolase enzyme that is responsible for fatal morbidities in the human
body, such as catheter encrustation, encephalopathy, peptic ulcers, hepatic coma, kidney …
body, such as catheter encrustation, encephalopathy, peptic ulcers, hepatic coma, kidney …
Synthesis, kinetic studies and in-silico investigations of novel quinolinyl-iminothiazolines as alkaline phosphatase inhibitors
Deposition of hydroxyapatite (HA) or alkaline phosphate crystals on soft tissues causes the
pathological calcification diseases comprising of end-stage osteoarthritis (OA), ankylosing …
pathological calcification diseases comprising of end-stage osteoarthritis (OA), ankylosing …
Contribution to the Synthesis, Characterization, Separation and Quantification of New N-Acyl Thiourea Derivatives with Antimicrobial and Antioxidant Potential
The present study aimed to synthesize, characterize, and validate a separation and
quantification method of new N-acyl thiourea derivatives (1a–1o), incorporating thiazole or …
quantification method of new N-acyl thiourea derivatives (1a–1o), incorporating thiazole or …
New Insight into the pharmacological importance of atropine as the potential inhibitor of AKR1B1 via detailed computational investigations: DFTs, ADMET, molecular …
SA Ejaz, M Aziz, A Ahmed, SS Alotaibi… - Applied Biochemistry …, 2023 - Springer
The aim of this research is to investigate the quantum geometric properties and chemical
reactivity of atropine, a pharmaceutically active tropane alkaloid. Using density functional …
reactivity of atropine, a pharmaceutically active tropane alkaloid. Using density functional …
Synthesis, Identification, Antioxidant, Molecular Docking, and In Silico ADME Study for Some New Derivatives Containing Thiourea Moiety
AA Maryoosh, OHR Al-Jeilawi - Russian Journal of Bioorganic Chemistry, 2024 - Springer
Objective: Synthesized a series of new thiourea (TU) derivatives, tested their antioxidant
activity, and investigated their expected biological activity by theoretical study …
activity, and investigated their expected biological activity by theoretical study …
Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review
RH Sharafat, A Saeed - Purinergic Signalling, 2024 - Springer
Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively
targeting ectonucleotidases, are essential in altering purinergic signaling pathways. The …
targeting ectonucleotidases, are essential in altering purinergic signaling pathways. The …
Design, synthesis, and in vitro and in silico studies of morpholine derived thiazoles as bovine carbonic anhydrase-II inhibitors
Carbonic anhydrase CA-II enzyme is essential for maintaining homeostasis in several
processes, including respiration, lipogenesis, gluconeogenesis, calcification, bone …
processes, including respiration, lipogenesis, gluconeogenesis, calcification, bone …