Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we
generated a prognostic LSC-associated miRNA signature derived from functionally …

▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing
cancer therapeutic target. Recent studies have investigated the mechanisms underlying the …

Mayo and Donner (1) report on yet another function of AKT, involving regulation of the
Mdm2p53 pathway. The first evidence pointing to a role of AKT in oncogenesis was …

The role of the serine/threonine protein kinase B (PKB, also known as Akt) is becoming
increasingly more evident to researchers investigating diverse cellular processes such as …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Obesity is recognized as a worldwide health crisis. Obesity and its associated health
complications such as diabetes, dyslipidemia, hypertension, and cardiovascular diseases …