Abstract Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by
endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Subcellular dysfunction and impaired metabolism derived from the complex interaction of
cytokines and mediators with cellular involvement are on the basis of the cardiovascular …

Tumor necrosis factor-alpha (TNF-α) is a pivotal mediator that triggers inflammatory process,
oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab …

Background The potent vasoconstrictor endothelin-1 has been implicated in the
pathogenesis of the microcirculatory dysfunction seen in sepsis. The mixed endothelin …

BACKGROUND: Microcirculatory dysfunction is a common feature of sepsis. The potent
vasoconstrictor endothelin (ET) is released in sepsis and endotoxemia, potentially …

Aims We evaluated whether pathophysiological events in the brain in sepsis are mediated
by ET-1/ET B receptor axis. Main methods We prepared raw fecal fluid from soft stool of …

Acute lung injury is an inflammatory syndrome that increases the permeability of the blood-
gas barrier, resulting in high morbidity and mortality. Despite intensive research, treatment …

Objective: Human cytochrome P450 2C9 (CYP2C9), CYP2C19, and CYP2D6
(corresponding to rat CYP2C11, CYP2C6V, and CYP2D3, respectively) are the major …

Even though severe sepsis and septic shock therapy has improved in recent years, mortality
remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut …