The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …

Most of the carbon fixed in primary production is rapidly cycled and remin-eralized, leaving
behind various forms of organic carbon that contribute to a vast reservoir of nonliving …

Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the
accuracy of translation, yet the physiological consequence of having fewer protein synthesis …

Faithful translation of mRNA into the corresponding polypeptide is a complex multistep
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …

The emergence and spread of multidrug-resistant strains of Mycobacterium tuberculosis
remains a major concern of tuberculosis control programmes worldwide, as treatment …

Errors are inherent in all biological systems. Errors in protein translation are particularly
frequent giving rise to a collection of protein quasi-species, the diversity of which will vary …

The translation of genes into functional proteins involves error. Mistranslation is a known
cause of disease, but, surprisingly, recent studies suggest that certain organisms from all …

Transfer RNA is an essential adapter molecule that is found across all three domains of life.
The primary role of transfer RNA resides in its critical involvement in the accurate translation …

Speed and accuracy of protein synthesis are fundamental parameters for the fitness of living
cells, the quality control of translation, and the evolution of ribosomes. The ribosome …

Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …