Prodrugs Design Based on Inter‐and Intramolecular Chemical Processes

R Karaman - Chemical biology & drug design, 2013 - Wiley Online Library
This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

Targeted prodrugs in oral drug delivery: the modern molecular biopharmaceutical approach

A Dahan, M Khamis, R Agbaria… - Expert opinion on drug …, 2012 - Taylor & Francis
Introduction: The molecular revolution greatly impacted the field of drug design and delivery
in general, and the utilization of the prodrug approach in particular. The increasing …

Theoritical evaluation of Citrus Aurantium leaf extract as green inhibitor for chemical and biological corrosion of mild steel in acidic solution: Statistical, molecular …

AA Khadom, MM Kadhim, RA Anaee… - Journal of Molecular …, 2021 - Elsevier
Citrus Aurantium extract consists of many compounds such as Alpha terpineol (AT), Linalool
(LI), Linalyl acetate (LA), and Monoterpene hydrocarbons (MH) that suggested as corrosion …

Promising bio-active complexes of platinum (II) and palladium (II) derived from heterocyclic thiourea: Synthesis, characterization, DFT, molecular docking, and anti …

AS Faihan, MR Hatshan, MM Kadhim… - Journal of Molecular …, 2022 - Elsevier
Abstract Four Platinum (II) and Palladium (II) heterocyclic thiourea complexes have been
prepared;[Pt (CPPT) 2](1),[Pd (CPPT) 2](2),[Pt (MPPT) 2](3), and [Pd (MPPT) 2](4)(Where …

Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios

A Di Pizio, A Levit, M Slutzki, M Behrens… - Methods in cell …, 2016 - Elsevier
G protein-coupled receptors (GPCRs) are seven transmembrane (TM) proteins that play a
key role in human physiology. The GPCR superfamily comprises about 800 members …

Taste masking approaches for medicines

W Faisal, F Farag, AAH Abdellatif… - Current drug delivery, 2018 - ingentaconnect.com
Undesirable taste is an important problem for patient compliance. Several oral
pharmaceuticals and bulking agents have disagreeable and bitter-tasting components. The …

Prodrugs for masking bitter taste of antibacterial drugs—a computational approach

R Karaman - Journal of molecular modeling, 2013 - Springer
DFT calculations for the acid-catalyzed hydrolysis of several maleamic acid amide
derivatives revealed that the reaction rate-limiting step is determined on the nature of the …

The future of prodrugs–design by quantum mechanics methods

R Karaman, B Fattash, A Qtait - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: The revolution in computational chemistry greatly impacted the drug design
and delivery fields, in general, and recently the utilization of the prodrug approach in …

[PDF][PDF] Theoretical investigation on reaction pathway, biological activity, toxicity and NLO properties of diclofenac drug and its ionic carriers

MM Kadhim, RM Kubba - Iraqi Journal of Science, 2020 - iasj.net
The present study included the use of the approximate semi-experimental method, the time-
independent density function theory (unrestricted), the timedependent density function …

Strategies for taste masking of orodispersible dosage forms: Time, concentration, and perception

J Yu, J Xie, H Xie, Q Hu, Z Wu, X Cai, Z Guo… - Molecular …, 2022 - ACS Publications
Orodispersible dosage forms, characterized as quick dissolving and swallowing without
water, have recently gained great attention from the pharmaceutical industry, as these forms …