Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

G Nygaard, GS Firestein - Nature Reviews Rheumatology, 2020 - nature.com
Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Podoplanin in inflammation and cancer

M Quintanilla, L Montero-Montero, J Renart… - International journal of …, 2019 - mdpi.com
Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Roles of podoplanin in malignant progression of tumor

H Suzuki, MK Kaneko, Y Kato - Cells, 2022 - mdpi.com
Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor
development and normal development of the lung, kidney, and lymphatic vascular systems …

Podoplanin: emerging functions in development, the immune system, and cancer

JL Astarita, SE Acton, SJ Turley - Frontiers in immunology, 2012 - frontiersin.org
Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in
multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney …

Dynamics of the transition from osteoblast to osteocyte

SL Dallas, LF Bonewald - Annals of the New York Academy of …, 2010 - Wiley Online Library
Osteocytes are derived from osteoblasts and make up over 90% of the cells in bone.
However, the mechanisms that control the differentiation of osteoblasts into osteocytes …

Podoplanin: an emerging cancer biomarker and therapeutic target

H Krishnan, J Rayes, T Miyashita, G Ishii… - Cancer …, 2018 - Wiley Online Library
Podoplanin (PDPN) is a transmembrane receptor glycoprotein that is upregulated on
transformed cells, cancer associated fibroblasts and inflammatory macrophages that …

Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton

A Wicki, F Lehembre, N Wick, B Hantusch, D Kerjaschki… - Cancer cell, 2006 - cell.com
The expression of podoplanin, a small mucin-like protein, is upregulated in the invasive front
of a number of human carcinomas. We have investigated podoplanin function in cultured …

What is new in cancer-associated fibroblast biomarkers?

Z Zhao, T Li, Y Yuan, Y Zhu - Cell Communication and Signaling, 2023 - Springer
The tumor microenvironment is one of the important drivers of tumor development. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and actively …

Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition

E Martín-Villar, D Megías, S Castel… - Journal of cell …, 2006 - journals.biologists.com
Podoplanin is a small membrane mucin expressed in tumors associated with malignant
progression. It is enriched at cell-surface protrusions where it colocalizes with members of …

Molecular analysis of the pathophysiological binding of the platelet aggregation‐inducing factor podoplanin to the C‐type lectin‐like receptor CLEC‐2

Y Kato, MK Kaneko, A Kunita, H Ito… - Cancer …, 2008 - Wiley Online Library
The mucin‐type sialoglycoprotein podoplanin (aggrus) is involved in tumor cell‐induced
platelet aggregation and tumor metastasis. C‐type lectin‐like receptor‐2 (CLEC‐2) was …