[HTML][HTML] Orientia and Rickettsia: different flowers from the same garden

JJ Gillespie, J Salje - Current Opinion in Microbiology, 2023 - Elsevier
Recent discoveries of basal extracellular Rickettsiales have illuminated divergent
evolutionary paths to host dependency in later-evolving lineages. Family Rickettsiaceae …

Type 1 secretion system and effectors in Rickettsiales

DC Bui, T Luo, JW McBride - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Obligate intracellular bacteria in the order Rickettsiales are transmitted by arthropod vectors
and cause life-threatening infections in humans and animals. While both type 1 and type 4 …

Ehrlichia Wnt SLiM ligand mimic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis

CD Byerly, LNL Patterson, NA Pittner… - Infection and …, 2023 - Am Soc Microbiol
Ehrlichia chaffeensis TRP120 effector has evolved short linear motif (SLiM) ligand mimicry to
repurpose multiple evolutionarily conserved cellular signaling pathways, including Wnt …

Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis

LNL Patterson, CD Byerly, R Solomon… - Infection and …, 2023 - Am Soc Microbiol
Ehrlichia chaffeensis has evolved multiple strategies to evade innate defenses of the
mononuclear phagocyte. Recently, we reported the E. chaffeensis tandem repeat protein …

Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program

CD Byerly, S Mitra, LNL Patterson, NA Pittner… - PLoS …, 2022 - journals.plos.org
Ehrlichia chaffeensis (E. chaffeensis) has evolved eukaryotic ligand mimicry to repurpose
multiple cellular signaling pathways for immune evasion. In this investigation, we …

Ehrlichia effector TRP120 manipulates bacteremia to facilitate tick acquisition

T Zhang, RC Chien, K Budachetri, M Lin, P Boyaka… - Mbio, 2024 - Am Soc Microbiol
Ehrlichia species are obligatory intracellular bacteria that cause a potentially fatal disease,
human ehrlichiosis. The biomolecular mechanisms of tick acquisition of Ehrlichia and …

Ehrlichia effector SLiM-icry: Artifice of cellular subversion

NA Pittner, RN Solomon, DC Bui… - Frontiers in Cellular and …, 2023 - frontiersin.org
As an obligately intracellular bacterial pathogen that selectively infects the mononuclear
phagocyte, Ehrlichia chaffeensis has evolved sophisticated mechanisms to subvert innate …

Ehrlichia chaffeensis TRP120 ubiquitinates tumor suppressor APC to modulate Hippo and Wnt signaling

CD Byerly, B Zhu, PA Warwick… - Frontiers in Cell and …, 2024 - frontiersin.org
Ehrlichia chaffeensis: TRP120 is a multifunctional effector that acts as a ligand mimic to
activate evolutionary conserved eukaryotic signaling pathways Notch, Wnt, Hedgehog and …

[HTML][HTML] Host Cells Upregulate Phosphate Transporter PIT1 to Inhibit Ehrlichia chaffeensis Intracellular Growth

M Li, N Yang, X Li, N Duan, S Qin, M Wang… - International Journal of …, 2024 - mdpi.com
Ehrlichia chaffeensis infects and proliferates inside monocytes or macrophages and causes
human monocytic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis. After …

[HTML][HTML] Ehrlichia Wnt short linear motif ligand mimetic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis

CD Byerly, LNL Patterson, NA Pittner, RN Solomon… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Ehrlichia chaffeensis TRP120 effector has evolved short linear motif (SLiM) ligand mimicry to
repurpose multiple evolutionarily conserved cellular signaling pathways including Wnt …