The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Normal insulin secretion requires the coordinated functioning of β-cells within pancreatic
islets. This coordination depends on a communications network that involves the interaction …

Although the heteromeric combination of type 1 taste receptors 2 and 3 (T1r2+ T1r3) is well
established as the major receptor for sugars and noncaloric sweeteners, there is also …

Drug repurposing, also known as repositioning or reprofiling, has emerged as a promising
strategy to accelerate drug discovery and development. This approach involves identifying …

Gasotransmitters are lipid soluble, endogenously produced gaseous signaling molecules
that freely permeate the plasma membrane of a cell to directly activate intracellular targets …

Abstract Background The divalent cation Calcium (Ca 2+) regulates a wide range of
processes in disparate cell types. Within insulin-producing β-cells, increases in cytosolic Ca …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Ion channels are transmembrane proteins that conduct specific ions across biological
membranes. Ion channels are present at the onset of many cellular processes, and their …

Opening of potassium channels on vascular smooth muscle cells with resultant
hyperpolarization plays a central role in several mechanisms of vasodilation. For example …