Abstract Angiotensin-converting enzyme 2 (ACE2) is a protein consisting of two domains,
the N-terminus is a carboxypeptidase homologous to ACE and the C-terminus is …

Renin angiotensin system (RAS) is an endocrine system widely known for its physiological
roles in electrolyte homeostasis, body fluid volume regulation and cardiovascular control in …

We examined cell type-specific expression and distribution of rat brain angiotensin-
converting enzyme 2 (ACE2), the receptor for SARS-CoV-2, in the rodent brain. ACE2 is …

Brain renin angiotensin system within the paraventricular nucleus plays a critical role in
balancing excitatory and inhibitory inputs to modulate sympathetic output and blood …

In December 2019, a novel coronavirus known as severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) emerged in Wuhan, the capital of Hubei, China. The virus …

Endoplasmic reticulum is a principal organelle responsible for folding, post-translational
modifications and transport of secretory, luminal and membrane proteins, thus palys an …

The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2
(ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood–brain …

Because of the presence of the blood–brain barrier, brain renin–angiotensin system activity
should depend on local (pro) renin synthesis. Indeed, an intracellular form of renin has been …

Nakagawa and Sigmund Regulation of the Brain RAS 11 processing proteases including
tonin and cathepsin G with a broad spectrum of substrate affinities. 27 Ang-(1–12), a peptide …

Abstract Purpose of Review The renin-angiotensin system (RAS) plays an important role in
modulating cardiovascular function and fluid homeostasis. While the systemic actions of the …