Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …

Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue,
obesity-mediated insulin resistance correlates with the accumulation of proinflammatory …

Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying
mechanisms are poorly understood. We describe an mTOR-driven mouse model that …

Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is
important for very low-density lipoprotein (VLDL) production and thus energy distribution to …

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …