Metabolic syndrome as a risk factor for Alzheimer's disease: a focus on insulin resistance
A Ezkurdia, MJ Ramírez, M Solas - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the main type of dementia and is a disease with a profound
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …
Advance of sporadic Alzheimer's disease animal models
L Zhang, C Chen, MSH Mak, J Lu, Z Wu… - Medicinal research …, 2020 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disease. In the past decades, numbers of promising drug candidates …
neurodegenerative disease. In the past decades, numbers of promising drug candidates …
Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced …
Z Guo, Y Chen, YF Mao, T Zheng, Y Jiang, Y Yan… - Scientific reports, 2017 - nature.com
Recent evidence reveals that aberrant brain insulin signaling plays an important role in the
pathology of Alzheimer's disease (AD). Intranasal insulin administration has been reported …
pathology of Alzheimer's disease (AD). Intranasal insulin administration has been reported …
Insulin resistance at the crossroad of Alzheimer disease pathology: A review
J Berlanga-Acosta, G Guillén-Nieto… - Frontiers in …, 2020 - frontiersin.org
Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus
countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; …
countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; …
7, 8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer's disease by reversing oxidative stress, mitochondrial dysfunction, and …
Abstract Rationale Intracerebroventricular (ICV) streptozotocin (STZ) mimics sporadic
Alzheimer's disease (SAD) characterized by tau pathology and neurodegeneration arising …
Alzheimer's disease (SAD) characterized by tau pathology and neurodegeneration arising …
The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model
L Zangerolamo, JF Vettorazzi, C Solon… - Molecular and cellular …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder and the major cause of dementia.
According to predictions of the World Health Organization, more than 150 million people …
According to predictions of the World Health Organization, more than 150 million people …
Pre-and post-treatment of α-Tocopherol on cognitive, synaptic plasticity, and mitochondrial disorders of the hippocampus in icv-streptozotocin-induced sporadic …
F Nabavi Zadeh, M Nazari, A Amini, S Adeli… - Frontiers in …, 2023 - frontiersin.org
Objective Most dementia cases in the elderly are caused by Alzheimer's disease (AD), a
complex, progressive neurological disease. Intracerebroventricular (ICV) administration of …
complex, progressive neurological disease. Intracerebroventricular (ICV) administration of …
Quercetin exhibits α7nAChR/Nrf2/HO-1-mediated neuroprotection against STZ-induced mitochondrial toxicity and cognitive impairments in experimental rodents
NK Singh, D Garabadu - Neurotoxicity Research, 2021 - Springer
The objective of the present study was to investigate the α7nAChR-mediated Nrf2-
dependant protective activity against streptozotocin (STZ)-induced brain mitochondrial …
dependant protective activity against streptozotocin (STZ)-induced brain mitochondrial …
[HTML][HTML] Bilateral intracerebroventricular injection of streptozotocin induces AD-like behavioral impairments and neuropathological features in mice: involved with the …
M Fan, S Liu, HM Sun, MD Ma, YJ Gao, CC Qi… - Biomedicine & …, 2022 - Elsevier
Abstract Objective To establish an Alzheimer's disease (AD) mouse model, investigate the
behavioral performance changes and intracerebral molecular changes induced by bilateral …
behavioral performance changes and intracerebral molecular changes induced by bilateral …
Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic …
SM Pacheco, MSP Soares, JM Gutierres… - The Journal of …, 2018 - Elsevier
Anthocyanins (ANT) are polyphenolic flavonoids with antioxidant and neuroprotective
properties. This study evaluated the effect of ANT treatment on cognitive performance and …
properties. This study evaluated the effect of ANT treatment on cognitive performance and …