The ability of living systems to adapt to changing conditions originates from their capacity to
change their molecular constitution. This is achieved by multiple mechanisms that modulate …

In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a
protein is determined by its amino acid sequence. This work laid the foundation for the …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

Alternative inclusion of exons increases the functional diversity of proteins. Among
alternatively spliced exons, tissue-specific exons play a critical role in maintaining tissue …

While sequencing of the human genome surprised us with how many protein-coding genes
there are, it did not fundamentally change our perspective on what a gene is. In contrast, the …

Abstract The Ensembl project (http://www. ensembl. org) is a comprehensive genome
information system featuring an integrated set of genome annotation, databases, and other …

Alternative splicing enhances proteome diversity and modulates cancer-associated proteins.
To identify tissue-and tumor-specific alternative splicing, we used the GeneChip Human …

Background RNA sequencing has opened new avenues for the study of transcriptome
composition. Significant evidence has accumulated showing that the human transcriptome …

Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for
transplantation. Means have been identified to overcome hyperacute rejection and acute …

Here, we present APPRIS (http://appris. bioinfo. cnio. es), a database that houses
annotations of human splice isoforms. APPRIS has been designed to provide value to …