According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Mass-spectrometry-based proteomics is continuing to make major contributions to the
discovery of fundamental biological processes and, more recently, has also developed into …

The intestinal microbiota is known to regulate host energy homeostasis and can be
influenced by high-calorie diets. However, changes affecting the ecosystem at the functional …

In this review we examine techniques, software, and statistical analyses used in label‐free
quantitative proteomics studies for area under the curve and spectral counting approaches …

In this review, we apply selected imputation strategies to label-free liquid chromatography–
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …

iTRAQ (isobaric tags for relative or absolute quantitation) is a mass spectrometry technology
that allows quantitative comparison of protein abundance by measuring peak intensities of …

Spectral count, defined as the total number of spectra identified for a protein, has gained
acceptance as a practical, label-free, semiquantitative measure of protein abundance in …

Quantitative shotgun proteomics is dependent on the detection, identification, and
quantitative analysis of peptides. An issue arises with peptides that are shared between …

Multiple testing corrections are a useful tool for restricting the FDR, but can be blunt in the
context of low power, as we demonstrate by a series of simple simulations. Unfortunately, in …

Glandular trichomes are metabolic cell factories with the capacity to produce large quantities
of secondary metabolites. Little is known about the connection between central carbon …