Non-invasive functional brain imaging is used more than ever to investigate pain in health
and disease, with the prospect of finding new means to alleviate pain and improve patient …

The ageing revolution is changing the composition of our society with more people
becoming very old with higher risks for developing both pain and dementia. Pain is normally …

Background Surgical outcomes in geriatric patients may be complicated by factors such as
multiple comorbidities, low functional performance, frailty, reduced homeostatic capacity …

Neuropathic pain due to a lesion or a disease of the somatosensory system often affects
older people presenting several comorbidities. Moreover, elderly patients are often poly …

Mast cell activation plays an important role in stress-mediated disease pathogenesis.
Chronic stress cause or exacerbate aging and age-dependent neurodegenerative diseases …

In dementia, neuropathological changes alter the perception and expression of pain. For
clinicians and family members, this knowledge gap leads to difficulties in recognizing and …

Introduction With minimal systemic toxicity, an analgesic effect of regional nerve block (RNB)
has been proved in hip fracture cases. Analgesia was expected to reduce delirium by …

Dementia is a progressive disease associated with irreversible impairment and loss of
cognitive abilities. About half of older people with dementia experience pain. In this paper …

For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …

As many countries experience population aging, patients with cancer are becoming older
and have more preexisting comorbidities, which include prevalent, age‐related, chronic …