Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …

Simple Summary Organometallics, such as copper compounds, are cancer
chemotherapeutics used alone or in combination with other drugs. One small group of …

Importance Disulfiram has demonstrated broad antitumoral effect in several preclinical
studies. One of the proposed indications is for the treatment of glioblastoma. Objective To …

Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas
(ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late‐stage diagnosis …

Copper is an essential trace element that plays a critical role in a variety of basic biological
functions, and serves as a key component in a number of copper-dependent enzymes that …

Disulfiram (DSF), a derivative of thiuram, has been used in humans to treat alcoholism for
more than 60 years. Over the past decade, however, increasing evidence indicates that DSF …

Flavonoids, a class of polyphenols are known to be effective inducers of apoptosis and
cytotoxicity in cancer cells. It is believed that antioxidant activity of polyphenols cannot fully …

Autophagy, a cellular survival mechanism, is thought to allow the recycling of cellular
breakdown products when cancer cells are subjected to chemotherapy, thus decreasing …

Unbalanced Cu homeostasis has been suggested to be associated with hematopoietic
disease, but the roles of Cu overload in the hematopoietic system and the potential …

Transition metals refer to the elements in the d and ds blocks of the periodic table. Since the
success of cisplatin and auranofin, transition metal‐based compounds have become a …