Computational approaches for identifying disease-causing mutations in proteins

M Pandey, SK Shah, MM Gromiha - Advances in protein chemistry and …, 2024 - Elsevier
Advancements in genome sequencing have expanded the scope of investigating mutations
in proteins across different diseases. Amino acid mutations in a protein alter its structure …

Progress on the development of prediction tools for detecting disease causing mutations in proteins

MM Gromiha, M Pandey, A Kulandaisamy… - Computers in Biology …, 2025 - Elsevier
Proteins are involved in a variety of functions in living organisms. The mutation of amino acid
residues in a protein alters its structure, stability, binding, and function, with some mutations …

Predicting the immune escape of SARS-CoV-2 neutralizing antibodies upon mutation

D Sharma, P Rawat, V Greiff, V Janakiraman… - … et Biophysica Acta (BBA …, 2024 - Elsevier
COVID-19 has resulted in millions of deaths and severe impact on economies worldwide.
Moreover, the emergence of SARS-CoV-2 variants presented significant challenges in …

TEMPO: A transformer-based mutation prediction framework for SARS-CoV-2 evolution

B Zhou, H Zhou, X Zhang, X Xu, Y Chai, Z Zheng… - Computers in Biology …, 2023 - Elsevier
The widespread of SARS-CoV-2 presents a significant threat to human society, as well as
public health and economic development. Extensive efforts have been undertaken to battle …

From Code to Cure: The Impact of Artificial Intelligence in Biomedical Applications

MM Gromiha, P Preethi, M Pandey - BioMedInformatics, 2024 - mdpi.com
Artificial intelligence (AI), a branch of computer science, involves developing intelligent
computer programs to mimic human intelligence and automate various processes. AI has …

SARS-CoV-2 variants infectivity prediction and therapeutic peptide design using computational approaches

CS Abhinand, AA Prabhakaran… - Journal of …, 2023 - Taylor & Francis
The outbreak of severe acute respiratory coronavirus 2 (SARS-CoV-2) has created a public
health emergency globally. SARS-CoV-2 enters the human cell through the binding of the …

Decoding the evolution of COVID-19 through mutational studies on SARS-CoV-2

D Sharma, P Rawat, MM Gromiha - … : Consequences on Structure …, 2025 - World Scientific
The COVID-19 pandemic had a major global impact and caused significant loss of lives.
SARS-CoV-2, the causative virus for COVID-19, harbors spike protein that interacts with the …

A Survey of COVID-19 Diagnosis Based on Deep Learning from X-ray Images and CT-Scan Images

J Wang, S Chen, H Zhu - International Conference on Computational & …, 2023 - Springer
The Coronavirus pandemic has been going on for three years. Undoubtedly, it caused huge
damage to people, physically and mentally. The earlier the doctor diagnoses, the sooner the …