Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review

MJ Millan - Progress in neurobiology, 2017 - Elsevier
The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

Long noncoding RNAs in aging and age-related diseases

S Kour, PC Rath - Ageing research reviews, 2016 - Elsevier
Aging is the universal, intrinsic, genetically-controlled, evolutionarily-conserved and time-
dependent intricate biological process characterised by the cumulative decline in the …

Long non-coding RNA and alternative splicing modulations in Parkinson's leukocytes identified by RNA sequencing

L Soreq, A Guffanti, N Salomonis… - PLoS computational …, 2014 - journals.plos.org
The continuously prolonged human lifespan is accompanied by increase in
neurodegenerative diseases incidence, calling for the development of inexpensive blood …

Silencing of long noncoding RNA XIST attenuated Alzheimer's disease‐related BACE1 alteration through miR‐124

D Yue, G Guanqun, L Jingxin, S Sen… - Cell biology …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder. However, its
pathogenetic mechanism is still poorly understood. An increasing number of studies have …

Identification of Alzheimer's disease–associated long noncoding RNAs

X Zhou, J Xu - Neurobiology of aging, 2015 - Elsevier
Alzheimer's disease (AD) is the most common dementia among the elderly that involves
complex neurodegenerative alterations. Multiple cellular processes including regulation of …

Epigenetic regulation of synaptic disorder in Alzheimer's disease

Z Chen, M Wu, Q Lai, W Zhou, X Wen… - Frontiers in Neuroscience, 2022 - frontiersin.org
Synapses are critical structures involved in neurotransmission and neuroplasticity. Their
activity depends on their complete structure and function, which are the basis of learning …

Expression of linear and circular lncRNAs in Alzheimer's disease

S Ghafouri-Fard, M Safari, M Taheri… - Journal of Molecular …, 2022 - Springer
Alzheimer's disease is a neurodegenerative disorder of the elderly described by progressive
cognitive debility. Recent studies have displayed the significance of linear and circular long …

Overexpression of lncRNA Gm15621 alleviates apoptosis and inflammation response resulting from sevoflurane treatment through inhibiting miR‐133a/Sox4

Y Zhao, Y Ai - Journal of cellular physiology, 2020 - Wiley Online Library
Sevoflurane is the most widely used anesthetic administered by inhalation. Exposure to
sevoflurane can elicit learning deficits and abnormal cognitive disorder. In this study, we …

[PDF][PDF] Impact of epigenetics in aging and age related neurodegenerative diseases

O Gangisetty, MA Cabrera… - Front Biosci (Landmark …, 2018 - article.imrpress.com
Epigenetics involves multiple processes such as DNA methylation, histone code
modifications, and noncoding RNAs to regulate gene expression. In recent years the …

The hypocretin/orexin neuronal networks in zebrafish

I Elbaz, T Levitas-Djerbi, L Appelbaum - Behavioral Neuroscience of …, 2017 - Springer
Abstract The hypothalamic Hypocretin/Orexin (Hcrt) neurons secrete two Hcrt
neuropeptides. These neurons and peptides play a major role in the regulation of feeding …