One of the most important metabolic hallmarks of cancer cells is enhanced lipogenesis.
Depending on the tumor type, tumor cells synthesize up to 95% of saturated and mono …

Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …

Heparin, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has
numerous important biological activities, associated with its interaction with diverse proteins …

▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a
large number of extracellular ligands. Members of both cell surface heparan sulfate …

Over the past decade, since it was first observed in vivo, there has been an explosion in
interest in the thin (∼ 500 nm), gel-like endothelial glycocalyx layer (EGL) that coats the …

▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These
complex polysaccharides provide docking sites for numerous protein ligands and receptors …

The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a
variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth …

The endothelial lining of blood vessels presents a large surface area for exchange of
materials between blood and tissues, and is critically involved in many other processes such …

The glycocalyx of the endothelium is an intravascular compartment that creates a barrier
between circulating blood and the vessel wall. The glycocalyx is suggested to play an …

Covering: up to August 2001This review covers the structure and function of heparin and
heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including …