Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …

As a permanent state of cell cycle arrest, cellular senescence has become an important
factor in aging and age-related diseases. As a central regulator of physiology and pathology …

Background Degenerative disc disease, a major cause of low back pain and associated
neurological symptoms, is a global health problem with the high morbidity, workforce loss …

Background The incidence of intervertebral disc degeneration (IVDD) is a common
degenerative disease with inflammation, decreased autophagy, and progression of fibrosis …

Low back pain (LBP) is a prevalent clinical condition that imposes substantial economic
burdens on society. Intervertebral disc degeneration (IVDD) is recognized as a major …

Background It has been demonstrated that vitamin D deficiency is associated with an
increased risk of patients developing lumbar disc herniation. However, intervertebral disc …

Chemonucleolysis has become an established method of producing whole organ culture
models of intervertebral disc (IVD) degeneration. However, the field needs more side-by …

Intervertebral disc degeneration (IDD) is an important pathological basis for degenerative
spinal diseases and is involved in mitophagy dysfunction. However, the molecular …

Due to the limited self-repair ability of the annulus fibrosus (AF), current tissue engineering
strategies tend to use structurally biomimetic scaffolds for AF defect repair. However, the …

Intervertebral disc degeneration (IVDD) is a leading cause of low back pain that incurs large
socioeconomic burdens. Growing evidence reveals that macroautophagy/autophagy …