CONTEXT AND OBJECTIVE: To present a summary of the 2nd International Consultation on
Bladder Cancer recommendations on the screening, diagnosis, and markers of bladder …

The development of cancer is associated with disorders in the regulation of the cell cycle.
The purpose of this review is to briefly summarize the known sequence of events that …

A major function of p27, also known as Kip1, is to bind and inhibit cyclin/cyclin-dependent
kinase complexes, thereby blocking cell cycle progression. As p27 operates at the heart of …

BACKGROUND: This study examined the clinical significance of CCNE1 (Cyclin E1)
amplification and assessed whether CCNE1 is a potential therapeutic target in ovarian …

Studies by comparative genomic hybridization revealed that the 19q13 chromosomal region
is frequently amplified in bladder cancer. The cyclin E gene (CCNE), coding for a regulatory …

Muscle-invasive urothelial (transitional cell) carcinoma is a potentially lethal condition for
which an attempt at curative surgery is required. Clinical staging does not allow for accurate …

The aim of this study was to evaluate the association between p53, p21, p27 and Rb
expression, alone or in combination, with pathological features and clinical outcomes of …

Bladder cancer is associated with high recurrence and mortality rates. These tumors show
vast heterogeneity reflected by diverse morphologic manifestations and various molecular …

Abstract Development of effective therapeutic modalities for the treatment of human cancer
relies heavily upon understanding the molecular alterations that result in initiation and …

Gastric cancer is thought to result from a combination of environmental factors and the
accumulation of specific genetic alterations due to increasing genetic instability, and …