In this Review, we explore natural product antibiotics that do more than simply inhibit an
active site of an essential enzyme. We review these compounds to provide inspiration for the …

Discovery of antibiotics acting against Gram-negative species is uniquely challenging due to
their restrictive penetration barrier. BamA, which inserts proteins into the outer membrane, is …

Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the
discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin …

The global spread of bacterial antimicrobial resistance is associated to millions of deaths
from bacterial infections per year, many of which were previously treatable. This, combined …

Combating anti-microbial resistance by developing alternative strategies is the need of the
hour. Cell division, particularly FtsZ, is being extensively studied for its potential as an …

The ability for bacteria to form boundaries between neighboring colonies as the result of
intra-species inhibition has been described for a limited number of species. Here, we report …

The prevalence of antimicrobial resistance in Gram-negative bacteria poses a greater
challenge due to their intrinsic resistance to many antibiotics. Recently, darobactins have …

The Resistance-nodulation-division (RND)-type AcrAB-TolC efflux pump contributes to
multidrug resistance in Gram-negative bacteria. Recently, the bacterium Photorhabdus …

Background Klebsiella pneumoniae is one of the main pathogens of clinical isolation and
nosocomial infections, as K. pneumoniae show broad-spectrum resistance to β-lactam and …