The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

There are currently at least forty-six unique protein kinase crystal structures, twenty-four of
which are available in an active state. Here we examine these structures using a structural …

WNK1 [with no lysine (K)] is a serine-threonine kinase associated with a form of familial
hypertension. WNK1 is at the top of a kinase cascade, leading to phosphorylation of several …

The crystal structure of the kinase domain from the epidermal growth factor receptor
(EGFRK) including forty amino acids from the carboxyl-terminal tail has been determined to …

Plants rely heavily on receptor-like kinases (RLKs) for perception and integration of external
and internal stimuli. The Arabidopsis regulatory leucine-rich repeat RLK (LRR-RLK) BAK1 is …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Plants and animals sense conserved microbial signatures through receptors localized to the
plasma membrane and cytoplasm. These receptors typically carry or associate with non …

▪ Abstract Plants harbor four families of kinases that have been implicated in Ca2+ signaling
(CDPKs, CRKs, CCaMKs, and SnRK3s). Although each family appears to respond to Ca2+ …

Importin α is the nuclear import receptor that recognizes classical monopartite and bipartite
nuclear localization signals (NLSs). The structure of mouse importin α has been determined …

Mutations in smooth muscle cell (SMC)-specific isoforms of α-actin and β-myosin heavy
chain, two major components of the SMC contractile unit, cause familial thoracic aortic …