Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins

PJ Mitchell, R Tjian - Science, 1989 - science.org
The cloning of genes encoding mammalian DNA binding transcription factors for RNA
polymerase II has provided the opportunity to analyze the structure and function of these …

The structure and function of the homeodomain

MP Scott, JW Tamkun, GW Hartzell III - Biochimica et Biophysica Acta (BBA) …, 1989 - Elsevier
'Homeotic'transformations are developmental anomalies in which one part of the body
develops iiJ the likeness of another. Many cases of homeosis were described and the …

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

RE Hill, J Favor, BLM Hogan, CCT Ton, GF Saunders… - Nature, 1991 - nature.com
SMALL eye (Sey) in mouse is a semidominant mutation which in the homozygous condition
results in the complete lack of eyes and nasal primordia. On the basis of comparative …

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

MH Rosner, MA Vigano, K Ozato, PM Timmons… - Nature, 1990 - nature.com
The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and
a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is …

New type of POU domain in germ line-specific protein Oct-4

HR Schöler, S Ruppert, N Suzuki, K Chowdhury… - Nature, 1990 - nature.com
MEMBERS of a family of murine octamer-binding proteins inter-act specifically with the
octamer motif, a transcription regulatory element found in the promoter and enhancer …

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

M Van Lohuizen, S Verbeek, B Scheljen, E Wientjens… - Cell, 1991 - cell.com
MO-MLV infection of Ep-myc transgenic mice results in a dramatic acceleration of pre-B ceil
iymphomagenesis. We have used provirus tagging to identify genes that cooperate with the …

Positional cloning and characterization of a paired box-and homeobox-containing gene from the aniridia region

CCT Ton, H Hirvonen, H Miwa, MM Weil, P Monaghan… - Cell, 1991 - cell.com
Based on the map location of the aniridia (AN) locus in human chromosomal band 11~ 13,
we have cloned a candidate AN cDNA (Dl lS812E) that Is completely or partially deleted in …

The POZ domain: a conserved protein-protein interaction motif.

VJ Bardwell, R Treisman - Genes & development, 1994 - genesdev.cshlp.org
We describe a novel zinc finger protein, ZID (zinc finger protein with interaction domain). At
its amino terminus ZID contains a 120-amino-acid conserved motif present in a large family …

Pax‐3, a novel murine DNA binding protein expressed during early neurogenesis.

MD Goulding, G Chalepakis, U Deutsch… - The EMBO …, 1991 - embopress.org
We describe the isolation and characterization of Pax‐3, a novel murine paired box gene
expressed exclusively during embryogenesis. Pax‐3 encodes a 479 amino acid protein with …

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

K Okamoto, H Okazawa, A Okuda, M Sakai… - cell, 1990 - cell.com
We have identified a novel octamer binding factor (Ott-3) in P19 embryonal carcinoma cells.
Ott-3, which recognizes the typical octamer motif (ATTTGCAT) as well as the AT-rich …