This article presents the revised consensus criteria for the diagnosis of frontotemporal
dysfunction in amyotrophic lateral sclerosis (ALS) based on an international research …

Frontotemporal dementia (FTD) has undergone numerous changes in nomenclature and
categorization schemes since it was first described by Pick in 1892. Presently, FTD …

The triggering of innate immune mechanisms is emerging as a crucial component of major
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is familial in
10% of cases. We have identified a missense mutation in the gene encoding fused in …

Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS)
cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial …

Ubiquitin-positive tau-negative neuronal cytoplasmic inclusions and dystrophic neurites are
common pathological features in frontotemporal lobar degeneration (FTLD) with or without …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized
pathologically by ubiquitinated TAR DNA binding protein (TDP-43) inclusions. The function …

Charcot described amyotrophic lateral sclerosis (ALS) in 1874. Despite progress, this
creeping paralysis, known colloquially as Lou Gehrig's disease, is still not visibly affected by …

Amyotrophic lateral sclerosis (ALS) is a genetically diverse disease. At least 15 ALS-
associated gene loci have so far been identified, and the causative gene is known in …

Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …