A core component to corticolimbic circuitry is the GABAergic interneuron. Neuroanatomic
studies conducted over the past century have demonstrated several subtypes of interneuron …

Animal modeling has been instrumental in dissecting pathophysiological mechanisms and
designing more effective therapies in many areas of medicine but not so in psychiatry. The …

Objective The cellular substrate of hippocampal dysfunction in schizophrenia remains
unknown. We tested the hypothesis that hippocampal interneurons are abnormal in …

Background: Recent studies have suggested that there may be a preferential decrease of
“nonpyramidal” neurons (NPs) in several corticolimbic regions of schizophrenic (SZ) brain …

Data from animal models and from postmortem studies suggest that schizophrenia is
associated with brain GABAergic dysfunction. The extent to which this is reflected in data …

This paper presents an overview of recent microscopic studies that have sought to define
how limbic circuitry may be altered in postmortem schizophrenic brain. The discussion is …

A variety of observations have suggested that the dopamine and serotonin systems may
play a role in the pathophysiology and treatment of major mental disorders of childhood …

Background: A recent study reported a decreased density of nonpyramidal neurons (NPs) in
layer II of the anterior cingulate (ACCx) and prefrontal (PFCx) cortices of schizophrenic brain …

The hippocampus is abnormal in schizophrenia. Smaller hippocampal volume is the most
consistent finding and is present already in the early stages of the illness. The underlying …

The hippocampus is crucial for normal brain function, especially for the encoding and
retrieval of multimodal sensory information. Neuropsychiatric disorders such as temporal …