Acute ischemic stroke is a leading cause of death and disability worldwide. Therapeutic
hypothermia has long been considered as one of the most robust neuroprotective strategies …

Therapeutic hypothermia (TH), which prevents irreversible neuronal necrosis and ischemic
brain damage, has been proven effective for preventing ischemia-reperfusion injury in post …

Drug resistance due to overexpression of membrane transporters in cancer cells and the
existence of cancer stem cells (CSCs) is a major hurdle to effective and safe cancer …

Selective therapeutic hypothermia (TH) showed promising preclinical results as a
neuroprotective strategy in acute ischemic stroke. We aimed to assess safety and feasibility …

The principle concept of treatment of acute ischemic stroke aims at reperfusion of the
ischemic region. 1 Reperfusion is the most intuitive countermeasure when blood has …

Stimuli-responsive nanoparticles hold great promise for drug delivery to improve the safety
and efficacy of cancer therapy. One of the most investigated stimuli-responsive strategies is …

Importance Epilepsy affects at least 1.2% of the population, with one-third of cases
considered to be drug-resistant epilepsy (DRE). For these cases, focal cooling therapy may …

A bulk of evidence from animal models indicates that lowering temperature by a few degrees
can confer neuroprotection against ischemia. 1 In humans, targeted temperature …

Therapeutic hypothermia (TH) is a potent neuroprotective therapy in experimental cerebral
ischemia, with multiple effects at several stages of the ischemic cascade. In animals, TH is …

Hypothermia is the most reliably effective neuroprotectant, and yet systemic complications
limit application. A large body of animal data suggests that hypothermia is effective for focal …