Articular cartilage is commonly described as a tissue that is made of up to 80% water, is
devoid of blood vessels, nerves, and lymphatics, and is populated by only one cell type, the …

Osteoarthritis is a painful joint disease characterized by progressive degeneration of the
articular cartilage as well as associated changes to the subchondral bone, synovium, and …

Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM)
that is both biochemically and biomechanically distinct from the extracellular matrix (ECM) of …

Mechanical loading of joints plays a critical role in maintaining the health and function of
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …

Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen
(COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic …

Biomechanical studies are expanding across a variety of fields, from biomedicine to
biomedical engineering. From the molecular to the system level, mechanical stimuli are …

Articular cartilage repair and regeneration continue to be largely intractable because of the
poor regenerative properties of this tissue. The field of articular cartilage tissue engineering …

Gelatin hydrogels can mimic the microenvironments of natural tissues and encapsulate cells
homogeneously, which makes them attractive for cartilage tissue engineering. Both the …

The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …

The pericellular matrix (PCM) is a narrow tissue region surrounding chondrocytes in articular
cartilage, which together with the enclosed cell (s) has been termed the “chondron.” While …