The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age‐related ocular diseases and other pathologies of the anterior and …

M Nita, A Grzybowski - Oxidative medicine and cellular …, 2016 - Wiley Online Library
The reactive oxygen species (ROS) form under normal physiological conditions and may
have both beneficial and harmful role. We search the literature and current knowledge in the …

A review of keratoconus: diagnosis, pathophysiology, and genetics

VM Tur, C MacGregor, R Jayaswal, D O'Brart… - Survey of …, 2017 - Elsevier
We discuss new approaches to the early detection of keratoconus and recent investigations
regarding the nature of its pathophysiology. We review the current evidence for its complex …

The genetic and environmental factors for keratoconus

A Gordon-Shaag, M Millodot… - BioMed research …, 2015 - Wiley Online Library
Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone‐
shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It …

The pathogenesis of keratoconus

AE Davidson, S Hayes, AJ Hardcastle, SJ Tuft - Eye, 2014 - nature.com
Keratoconus (KC) is a common degenerative condition that frequently results in visual loss
with an onset typically in early adulthood. It is the single most common reason for …

The keratoconus enigma: a review with emphasis on pathogenesis

G Ferrari, P Rama - The ocular surface, 2020 - Elsevier
Purpose To review the literature on the etiopathogenesis of keratoconus (KC). Methods A
literature search was conducted using PUBMED and Google Scholar for keratoconus. The …

Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy

KA Wojcik, A Kaminska, J Blasiak, J Szaflik… - International journal of …, 2013 - mdpi.com
Due to its localization and function, the cornea is regularly exposed to sunlight and
atmospheric oxygen, mainly dioxygen, which produce reactive oxygen species (ROS) …

Update on the genetics of keratoconus

Y Bykhovskaya, YS Rabinowitz - Experimental Eye Research, 2021 - Elsevier
In the past few years we have seen a great acceleration of discoveries in the field of
keratoconus including new treatments, diagnostic tools, genomic and molecular …

Genetics in Keratoconus: where are we?

Y Bykhovskaya, B Margines, YS Rabinowitz - Eye and Vision, 2016 - Springer
Keratoconus (KC) is a non-inflammatory thinning and protrusion of the cornea in which the
cornea assumes a conical shape. Complex etiology of this condition at present remains an …

Genetic aspects of keratoconus: a literature review exploring potential genetic contributions and possible genetic relationships with comorbidities

E Loukovitis, K Sfakianakis, P Syrmakesi… - Ophthalmology and …, 2018 - Springer
Introduction Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial
degenerative disorder that is accompanied by corneal ectasia which usually progresses …

Genetic and environmental risk factors for keratoconus

SEM Lucas, KP Burdon - Annual Review of Vision Science, 2020 - annualreviews.org
Keratoconus, a progressive corneal ectasia, is a complex disease with both genetic and
environmental risk factors. The exact etiology is not known and is likely variable between …